Phase Regulation of RNA Binding Protein
نویسندگان
چکیده
Living cells utilize liquid-liquid phase separation （LLPS） to enable the compartmentalization of macromolecules as membrane-less organelles. RNA binding proteins with intrinsically disordered regions play a central role in biological LLPS. Although LLPS provides an enormous advantage mixture wide variety macromolecules, misregulation leads fatal diseases, including Amyotrophic Lateral Sclerosis （ALS）. Phase state protein FUS and its regulation by nuclear import receptor karyopherinβ2 will be discussed.
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ژورنال
عنوان ژورنال: Journal of the Crystallographic Society of Japan
سال: 2022
ISSN: ['0369-4585', '1884-5576']
DOI: https://doi.org/10.5940/jcrsj.64.140